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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

After 5 min, the peptides were eluted with SCX Solvent B (25% MeCN, 5 mM KH 2 PO 4 , 500 mM KCl, pH 2.7) using a gradient from 0% to 50% B in 75 min followed by 50% to 100% B in 5 min and then maintained at 100% B for 10 min at a flow rate of 50 l/min (Supplementary Fig

Lohi, H

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+ The 50mg vial suits standard research protocols and shorter studies