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In parallel, astrocytes also release anti-inflammatory mediators such as orosomucoid-2 (ORM2), and TGF-beta, which prevent microglial activation [48] (Figure 3)

140 (Table 2) It is increasingly recognized that disturbances in urate transport, both in the gastrointestinal tract and kidneys, are pivotal in the pathogenesis of diseases associated with hyperuricemia

For a healthy functioning of the body, there must exist a balance between antioxidants and free radicals of the body

From these data we can reasoned that by selectively targeting GSH content of cancer cells we can induce apoptosis either directly or by combining therapies with redox antineoplastic agents