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10.1093/nsr/nwaa041 219 ZhouZ.XiangW.JiangY.TianN.WeiZ.WenX.et al (2020)

Retatrutide dosage escalation (Phase 2 trial protocol) The Phase 2 trial tested multiple starting dose strategies

The additional N-terminal sequence and amino acid substitution are believed to support its biological activity by potentially increasing its affinity for IGF receptors while reducing its binding to proteins that may deactivate it (1)