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Several studies have shown that METTL3 plays important regulatory roles in prostate cancer proliferation, migration, invasion, apoptosis, drug resistance androgen-induced splicing and glycolipid metabolism maintenance (125,126)

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Tsuji et al., 2009), and may contribute to brain Se transport under SELENOP or LRP8 deficiency

REDEFINE-1: adults with obesity, no diabetes Design: 3,417 adults with BMI 30 (or 27 with a comorbidity), without type 2 diabetes, for 68 weeks

Downregulating TRPML1 or blocking the interaction between TRPML1 and ARL8B can inhibit AKT-driven tumorigenesis by promoting ferroptosis, and enhancing the sensitivity of radiotherapy and immunotherapy