Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
MET is primarily expressed not only in epithelial and endothelial cells (Gentile et al., 2008) but also in myoblasts and neuronal precursors, contributing to the development of muscle and nervous structures (Bladt et al., 1995
For instance, an analysis of FAERS data (2014-2021) identified significant associations with interstitial lung disease (ILD) and pneumonitis, noting that 75.40% of events occurred within the first three months of treatment ( According to the latest raw statistics and our preliminary calculations from the FDA FAERS public dashboard ( In this context, a re-examination of the epidemiological features, temporal patterns, and clinical outcome differences of adverse events associated with PD-1/PD-L1 inhibitors is needed
Some individuals benefit from periodic treatments
The mechanism involves reshaping the gut microbiota (e.g., promoting Bifidobacteria growth), restoring key neurotransmitter (e.g., serotonin) balance, reducing inflammatory cytokine (e.g., TNF- ) levels, and promoting hippocampal neurogenesis
