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Ongoing challenges to trial conduct include the substances short half-life, the availability of unregulated commercial products, and ensuring protocol compliance

As always, careful consideration of dosage, safety, and legal compliance is essential when exploring these compounds

Its too risky, especially given the lack of research in people

Standard doses restore what aging has depleted

To date, incretin-based approaches for obesity management appear as the most promising and rapidly developing (Supplementary Table 1), with innovations such as once-weekly (OW) injectable triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), cagrilintide (long-acting amylin analogue)/semaglutide 2.4 mg (CagriSema) combination, GCGR/GLP-1R dual agonists, high-dose oral semaglutide, and oral non-peptide GLP-1 receptor agonist orforglipron, with relevant implications in terms of patients compliance and environmental sustainability