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APX differs from other peroxidases since it utilizes ascorbate (AsA) as its definite electron donor to reduce hydrogen peroxide to H 2 O with the consequent production of monodehydroascorbate (MDHA), a monovalent oxidant of ascorbate

284 Disintegration of glia limitans translates into the widespread damage to the bloodbrain barrier and degranulation of natural killer cells that release perforins and granzyme, which in turn, further injure astrocytes and endothelium

Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis

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The post-treatment improvement in hepatic markers suggests that glycine supplements should be investigated as a potential novel treatment for MASLD