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Methods: This analysis is based on the DETECT cohort (Prehospital GFAP Measurements for Diagnosing ICH in Acute Stroke)

Vemuri et al

This paradox arises from the inherent complexity of MS pathogenesis which we argue is driven by a convolution of relapsing/acute adaptive autoimmunity and chronic cytodegeneration (cyto-is used here rather than neuro-to underscore the point that myelin/oligodendrocytes are the likely primary targets of this process), including an elaborate innate immune response (Figure 1)

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Interestingly, the percentage of Kaede red + CD4 + T cells was highest in the synovial tissues (Fig