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On the other hand, FOXO4-DRI did not show significant toxicity in normal TM3 Leydig cells (Figure 5B5D), where expression of FOXO4 was low (Figure 3C3E)

82 JeongS

Note that 9 mg and 12 mg are now the Phase-3-validated doses, while 1 mg, 4 mg, and 8 mg remain Phase 2 / research reference points

In addition to its role in maintaining a normal sleep-wake cycle, melatonin plays an important part in autonomic regulation, including blood pressure, pulse, and temperature, as well as immune response and glucose homeostasis