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Upon UVA radiation, melanocytes emit extracellular vesicles laden with diverse cellular components notably miR-21 mediating the signal transduction in the keratinocytes and leading to their increased proliferation and heightened anti-apoptotic mechanisms, which links to the development of skin cancer [154].UVB irradiation could reduce the expression of miR-137 that could inhibit the tumorigenic phenotype in human epidermal melanocyte cell and increase the expression of miR-29a-3p and miR-183-5p that could downregulate the phosphatase and tensin homolog (PTEN) involved in the metastatic progression of cSCC [155,156,157]