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The -chain (69 kDa) comprises an N-terminal (N) hairpin-loop and 4 kringle domains (K1K4) while the -chain (3234 kDa) has a serine proteinase homology (SPH) domain (Rong et al., 1994

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Measurements of serum vitamin B 12 may not reliably detect deficiency, and measurement of serum homocysteine and/or methylmalonic acid should be used to confirm deficiency in asymptomatic high-risk patients with low normal levels of vitamin B 12