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It decreased the supersaturation of brushite [45], down-regulated the osteopontin (OPN) protein expression, increased superoxide dismutase (SOD), elevated Bcl-2 expression, and decreased the apoptotic index in the rat model of kidney stones [23]

Jun 13 2016;6(3):1549-1577

This blockade leads to rapid accumulation of norepinephrine within the synaptic cleft and prolonged activation of postsynaptic adrenergic receptors, producing enhanced sympathomimetic activity

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