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[DOI] [PubMed] [Google Scholar] 120.Coudray C, Faure P, Rachidi S, et al

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The role of the second HS-binding site is to bind an adjacent HS chain to minimize k off of the proteins, which may be particularly important during repeated direct Hh switching from one HS chain to the next during gradient formation ( R238;239A that becomes subjected to restricted diffusion akin to on/off binders with one binding site, and that subsequently leak from the apical side of the epithelial plane ( R238;239A was strongly overexpressed by the Gal4-UAS system-ectopic signaling further away from the source was induced by the freely diffusing protein to varying degrees

The efficacy and results will depend upon consistent use