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In pathologic conditions, the loss of HS disrupts the charge selectivity of the glomerular filtration barrier, which increases the filtration of proteins and leads to proteinuria (97)

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Higher doses (particularly 54 mg) showed somewhat increased gastrointestinal symptoms compared to lower doses

Research Applications & Usage Information Dihexa (8 mg) is commonly used for: HGF/c-Met receptor pathway studies Neurobiology and synaptic signaling research Cellular communication and growth factor signaling analysis Molecular pathway modeling in preclinical systems Investigations into receptor-binding and intracellular signaling Experimental studies of peptide-derived small molecule analogs All applications are investigational and intended for laboratory research use only

Additonal file 1: Figure S1B)