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But indulge me in a few thoughts on the cast and crew: besides Gandolfini and Sarandon, who carry the film on their shoulders, the standout is Kate Winslet, mostly unrecognisable in bright red hair, trashy lingerie and make-up, and a north country accent that sounds like rubbing a cat on a blackboard

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In selective reviews of the literature, Coggins (1998, 2002) summarized other nonneoplastic histopathologic changes observed in animals exposed to cigarette smoke: pulmonary fibrosis in C57 mice accompanied by accumulation of lymphocytes and macrophages in the peribronchiolar and perivascular regions