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Unlike compounds that rely heavily on hormonal pathways, the BPC-157 Peptide operates primarily through the upregulation of growth factors and the modulation of the nitric oxide (NO) system

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19 We speculate that patients with clEDS may be more prone to have structural defects along the walls of the gastrointestinal tract, which can predispose to diffuse diverticulosis, diverticulitis, and resulting bowel perforation as well as to perforation during invasive procedures and spontaneous perforation