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CYP1A1 activity increases 4.6-fold, leading to excessive free radical production and subsequent DNA damage, while CYP3A4 expression decreases by 68%, severely impairing steroid hormone metabolism ( 3.2.2.2 Glutathione system compromise The cellular antioxidant defense system suffers significant impairment, with GSH levels declining to 35% of normal values, substantially weakening antioxidant defenses

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