Telaglenastat plus cabozantinib or everolimus for advanced or metastatic renal cell carcinoma: an open-label phase I trial
Cracking the Folate Code: How Enzymatic Polymorphisms Shape Health and Neurodevelopment
Now we dont know if itll extend lifespan, but it does seem to do the same kind of things that metformin does, and metformin seems to have all the hallmarks of a lifespan-extending drug, so I think berberine is a good option. Sinclair notes one thing to consider: Berberine is also insoluble, so he suggests mixing it into yogurt or oil for better absorption and reduced side effects
Am J Clin Nutr 96: 332336, 2012 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Hansen JG, Tang W, Hootman KC, Brannon PM, Houston DK, Kritchevsky SB, Harris TB, Garcia M, Lohman K, Liu Y, de Boer IH, Kestenbaum BR, Robinson-Cohen C, Siscovick DS, and Cassano PA
The biological roles proposed for GHK-Cu in the research literature have included effects on collagen and extracellular matrix synthesis (through copper-dependent enzymes including lysyl oxidase), on antioxidant gene networks (where copper participates in both prooxidant and antioxidant chemistry depending on context), on growth factor activity in tissue repair, on hair follicle biology, and on broader transcriptional programs characterized in microarray and RNA-seq studies
