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When the majority of that literature originates from a single research group, uses the same animal model, and has not been independently replicated, the effective evidence base is narrower than the publication count implies

By including a specific protease cleavage site between the GST tag and the recombinant protein, the tag can be cleaved off post-purification

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Regulation of astrocyte glutamine synthetase in epilepsy

By binding to p53, it induces nuclear exclusion, allowing p53 to translocate to the cytoplasm and mitochondria, subsequently activating the p53/BCL-2/Caspase-3 signaling pathway to execute selective apoptosis in senescent populations (Frontiers, 2025