In turn, this phenomenon can triggers a catalytic mechanism for the oxidation of the cellular thiol pool [117,118,119] and of oxidative stress when the homeostatic compensation is overwhelmed by an excessive depletion of the reduced thiol pool, as is the case for cells, such as neurons, that depend on neighboring glial cells for their supply of essential thiol precursors
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Every year, approximately 300-500 million people suffer from malaria globally, and 94% of those cases are reported in the African region [210, 397,398,399]