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10.1007/s10930-022-10074-5 13 HepsomaliP.GroegerJ

Estudos toxicolgicos no identificaram dose txica mnima, dose letal ou efeitos teratognicos/genotxicos

A., Grumbach, M

The peptide demonstrates dual-phase mechanisms: acute phase preservation of ischemic tissue through anti-apoptotic signaling via Akt activation, and chronic phase activation of cardiac progenitor cells (c-kit+ populations) that contribute to myocardial repair through both structural replacement and paracrine support, with studies showing 200% increases in progenitor cell mobilization and cardiac homing