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Its triple GIP/GLP-1/glucagon agonist mechanism produced the most striking weight-loss numbers ever reported in a Phase 2 trial of an injectable peptide, and its broad TRIUMPH Phase 3 program is poised to expand understanding of how triple receptor modulation affects obesity, diabetes, liver disease, cardiovascular risk, sleep apnea, and musculoskeletal health

10.1016/j.snb.2019.05.046 261 RamzanA.MehmoodA.AshfaqR.AndleebA.ButtH.ZulfiqarS.et al (2023)

Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

Never store reconstituted peptides at room temperature or freeze them after reconstitution unless youre creating single-use aliquots that will only be thawed once

Immunity 48, 380395.e6