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The same steps were repeated except we used the first 20 principal components for clustering, uniform manifold approximation and projection, and t -SNE plots

Besides being a potential source of more reactive free radicals via Fenton reaction, physiological generation of H 2 O 2 fulfills a second messenger role and can be transported across membranes by aquaporins, a family of proteins that act as peroxiporins (Sies, 2014)

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8 BizzottoJ.SanchisP.AbbateM.Lage-VickersS.LavignolleR.ToroA.et al (2020)

For the primary cells, 2 subsets of CLL lymphocytes were tested: proliferating cells (supplemented with CD40 ligand and interleukin-4) and quiescent cells