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In PCOS, hyperglycemia-induced oxidative stress may be capable of directly promoting hyperandrogenism

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J Biol Chem 277:3288332891 Tanizawa Y, Nakai K, Sasaki T et al (2002) Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase

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