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Aronne LJ et al., SURMOUNT-5 head-to-head, NEJM 2024 (NEJMoa2416394) : tirzepatide vs semaglutide, advantage tirzepatide of approximately 6 points

These results indicated that PGC-1 functioned as a downstream effector of DDIT4

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In one experimental study, female mice, but not their male counterparts, showed significant elevations in hepatic triglyceride and phosphatidylcholine levels after exposure to e-vapor composed exclusively of glycerol, without nicotine or flavoring agents [121]