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These inhibitors bind to the enzymes active site, effectively blocking its activity

Folkert IW, Mehran R, Sun R, Morris VK, Overman MJ, Kee B, Antonoff MB, Tzeng CW, Dasari A, Tran Cao H, Parseghian CM, Vilar E, Willis J, Newhook TE, Hofstetter W, Kopetz SE

Failure to comply with this is deemed, under the guidelines, to be a serious breach of Administrative Guideline and the Finance Instruction

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