4.1 Restoration of skin barrier integrity Disruption of the skin barrier, comprising the stratum corneum, lamellar lipids, tight junctions, and cutaneous microbiota, is a central pathophysiological hallmark of AD, as part of the broader mechanisms illustrated in Figure 4
A6: Many Glutathione products are formulated to be gentle on the skin
This, in turn, further disrupts GBA activity by hindering its trafficking from the endoplasmic reticulum to the Golgi to lysosomes, ultimately contributing to neurodegeneration [117]
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