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484,485 UPS dysregulation in SLE: autoantibodies, antigen processing, and immune signaling In SLE, aberrant UPS activity contributes to inflammatory pathways, defective antigen presentation, and impaired apoptotic processes

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This is because autopsy and biomarkerbased studies 25 , 83 , 295 , 296 , 297 indicate that some individuals counted as having Alzheimer's dementia based on symptoms do not have the biological brain changes defined as Alzheimer's disease

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