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The Chronic Patient: Perhaps more tragic is the patient who suffered a concussion months or years ago and is told they have reached a "clinical plateau." They are told their headaches, brain fog, and fatigue are permanent because their MRI is "normal." This is a false premise

In addition, the cytokines IL-1, IL-6 and IFN- may be potential targets for treating patients with IBD who do not respond to anti-TNF therapy

Discussion As of early 2024, more than 34,000 patients in the United States have received autologous CAR T cells, mainly targeting CD19 for hematological malignancies 21

Zhang X, Beynen AC

Ethical approval This article does not contain any studies with human participants or animals performed by any of the authors, except for those published previously and approved by respective ethic committees