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Since the purpose of endocytic recycling is to eliminate damaged proteins, it is possible that the spike protein, acting through ACE2, conferred some form of damage or instability on the CFTR

Wang P, Afriyie-Gyawu E, Tang Y, Johnson NM, Xu L, Tang L, et al

At the same time, interrupting the electron transport chain by binding of NO to complex IV increases electron release, thus facilitating the formation of reactive oxygen species, firstly superoxide anion and subsequently H 2 O 2 and OH

Additionally, physicians need to remain aware of the large body of evidence showing a positive effect of antioxidants in the period following chemotherapy administration

References: Katoulis et al