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Lung cancer stem cells further remodel metastatic potential via exosomal Mir100hg, which enhances glycolysis (via ALDOA) to raise lactate and induce H3K14la at promoters of metastasis-associated genes (e.g., LMAN1, OSTC, P4HA1), activating pro-metastatic transcriptional programs and increasing colonization in vivo [192]

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A well-known risk factor in humans is hypercholesterolemia, i.e., elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) (Pourrajab et al., 2021), and other important contributors to this disease include inflammation, oxidative stress and insulin resistance (Subramani et al., 2017)

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