Following induction of lung metastasis, IGF1R-deficient lungs also demonstrated a reduced tumor burden, and decreased expression of tumor progression markers, p-IGF1R and p-ERK1/2
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Ferroptosis has also been reported to be associated with damage to the locus coeruleus noradrenergic neuronal degeneration, and the occurrence of non-motor symptoms such as learning and memory dysfunction, which take place in the early stage of PD (Hou et al., 2019b)