doi: 10.3390/antiox9030218
Nevertheless, most of the in vivo studies assessing human intestinal permeability (oral administration of sugars or other probes later detected in blood or urine) mainly target the paracellular pathway
202,203,204,205,206,207,208,209 Utilizing data from observational epidemiologic studies in conjunction with experimental evidence from in vitro and animal model investigations, elevated serum urate levels have been suggested as being potentially linked to concurrent metabolic disorders
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This is particularly useful considering the crucial role glutathione plays in human health and a wide range of diseases