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Laezza and Dingledine, 2004

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The studies included used needle depths ranging from 0.5 mm to 2.5 mm

It is likely that a dysbiosis arises in these conditions in which a decrease of beneficial bacteria and their metabolic byproducts occurs along with an increase in detrimental microbial populations and their toxic metabolites, leading to an altered luminal environment [106]

Sikiric et al., 2020b) without toxicity (lethal dose 1 (LD1) could be not obtained) (Sikiric et al., 1993