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If any part of this signaling chain is disrupted by inflammation, oxidative stress, or nutrient depletion, the cells become "deaf" to insulin's signala state known as insulin resistance

doi: 10.1002/glia.23179 123 KellerJZackowskiKKimSChidobemISmithMFarhadiFet al

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As shown in Table 1, many infections caused by intracellular pathogens result in a 2-4-fold decrease in the GSH: GSSG ratio of the host cell 2,21,22,23,24,25,26,27,28,29,30,31,32,33

Involvement of reduced microbial diversity in inflammatory bowel disease