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Consequently, Nrf2 is released and translocates into the nucleus, where it forms a heterodimer with Maf proteins and binds to antioxidant response elements (AREs) in the genome [95]

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et al., 2016), protein misfolding (Kopito, 2000

Selenium is a component of glutathione peroxidase, an antioxidant enzyme that acts like a shield, protecting the gland from oxidative stress and inflammation

It is noteworthy that such delivery challenges are not unique to SFN but represent a common hurdle for many bioactive phytochemicals, as comprehensively documented in the case of curcumin where nano-formulations have successfully addressed similar bioavailability limitations