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Even though, considering the essentiality of copper in humans, the copper hypothesis of GHK mechanism of action seems very attractive, recent gene data may challenge this mechanism and demand more studies into GHKs mechanism of action

Furthermore, the overexpression of BMP6 suppressed the Wnt10b level in HFSCs

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These observations help identify the actual source

Additionally, direct supplementation of monounsaturated fatty acids (MUFAs) in the diet to replace PUFA, which is prone to lipid peroxidation on cell membranes, can prevent the accumulation of lipid ROS and the occurrence of ferroptosis [295]