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The cells that overexpressed the transporters have been found to contain low levels of 6-TGN and other thiopurine metabolites ( thiopurine cellular circulation , whereby thiopurine nucleotides extruded by ABCC4 will be salvaged by an extracellular enzyme NT5E through hydrolysis into nucleosides, before being transported back into the cells by nucleoside transporters ( Finally, several genetic markers and enzymes have been reported to cause thiopurine resistance, but the mechanisms are obscure

Another study was conducted similarly in both obese and lean mice

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2000 Sep-Dec;22(5-6):384-92

based on consistent formation of -helical structure in initial rounds of structure calculations in which no hydrogen bond restraints were defined)