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10.2147/DDDT.S171286 112 NanM.Rui-ZhiT.Shao-QingW.CongW.Xin-LiS.Jun-MingF.et al (2016)

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Although, compared to younger ages and nTg neurons, 3xTg-AD neurons cultured in vitro under constant and controlled conditions have a defined genotype with human APP (SWE), PS1 (M146V), and Tau (P301L) transgenes to mimic neuropathological features of familial AD, they are limited in application because of the relative overproduction of APP in this model

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However, verapamils dual effects on drug metabolism, particularly its inhibition of CYP3A activity, raise concerns about potential interactions with essential TB drugs like rifampin, which is known to induce CYP3A enzymes [87]