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B12 supplements may improve heart health by reducing homocysteine levels, a compound that is associated with an increased risk of heart disease

Cochrane Database Syst Rev

Proponents of B12 shots claim they turbocharge the metabolism (read: make you thinner), strengthen the immune system, and help cure fatigue, insomnia, even depression

Your deltoid muscle (upper arm) absorbs B12 completely differently than your glute muscle