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This process is a multifaceted and intricate regulatory mechanism, with multiple pathways mediating mitophagy demonstrating parallelism or redundancy to preserve the equilibrium between mitochondrial homeostasis and the mitochondrial quality control system (Figure 3)

They target aging through entirely different mechanisms, which means the comparison matters more for sequencing and stacking than for choosing one over the other

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

This high GSH/GSSG ratio ensures a reducing cytosolic redox potential, and most cytosolic sulfhydryl groups are present as free thiols rather than oxidized disulfides