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In tau transgenic mice we saw improvements in brain structure and function by reducing senescent cell burden by 30% with an intermittent treatment strategy (35), which is consistent with preclinical studies on other models of aging and/or disease (37, 45, 46, 101103, 108112)

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TB-500 is studied in models involving actin regulation, cell migration, angiogenesis, vascular response, and tissue remodeling

decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models