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Description

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When the majority of that literature originates from a single research group, uses the same animal model, and has not been independently replicated, the effective evidence base is narrower than the publication count implies

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Although TET members such as TET2 functions as tumor suppressor in certain cancers including AML and glioma 45 , we showed that knockdown of individual TET members consistently abrogates the YBX1AMPK axis in liver and lung cancer cells, suggesting potential functional synergy among TET members in regulating local DNA demethylation, although the underlying mechanisms warrant further investigation

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