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PMID: 31278276

The use of PEG for modification of drugs is FDA approved, non-immunogenic, non-antigenic, non-toxic, and increases the solubility of drugs in aqueous solutions

Bauman MD, Lesh TA, Rowland DJ, Schumann CM, Smucny J, Kukis DL, et al

This supports its use in TM and highlights its potential for development as an anti-HTN drug (274)

The study also revealed an unexpected pathway-dependent response: in telomerase-positive cancer cell lines, telomere elongation occurred through alternative lengthening of telomeres (ALT) activation rather than telomerase upregulation, suggesting that the AEDG sequences interaction with telomere maintenance pathways is more complex than initially characterized