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Disclosures Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work

5 Conclusion and future perspectives With the increase in the use of digital devices and the population aging, DED has become a common concern in contemporary society

SPIERECTOR has been shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, wound and fracture (pseudoarthrosis) healing, bone and joint healing, and organ damage

ROS-induced fluorescence was quantitated using a Cellomics ArrayScan VTI HCS reader (ThermoFisher Scientific) and normalized to cell number

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