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HBECs were placed in sterile Ringers solution (in mM) 120 NaCl, 5.2 KCl, 1.2 MgCl 2 , 1.2 CaCl 2 .2H 2 O, 12 NaHCO 3 , 24 HEPES, 10 glucose, pH 7.4 during the exposure

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Although all studies consistently indicated a statistically significant link between e-cigarette use and the odds of having COPD, the selected studies exhibited high heterogeneity ( I 2 = 98.85%), and the prediction interval for the ORs was 0.84 to 4.92 (Figure 2A)