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rustica is a hardy plant and can be grown in most of Russia (as opposed to other Nicotiana species which require a warm climate), it was more readily and cheaply available, and did not depend on transport in a country with an underdeveloped road network and climatic portage problems

A second KRAS G12C G12C inhibitor, adagrasib (MRTX849), has also produced promising outcomes in clinical trials [121, 122] and several other KRAS G12C inhibitors have entered clinical studies [123]

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