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16 However, the phenotype presented by JAM-A-null mice mirrored the phenotype presented by mice subjected to the transient breach in the barrier function before their exposure to acute colitis, to a great extent

5.3 Metabolic and barrier dysfunction The oral microbiota dysbiosis associated with periodontitis disrupts the intestinal microenvironment through metabolic regulation and impaired barrier function, contributing to the pathogenesis of depression

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Clin Microbiol Rev 22: 240273