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Penetration Enhancement Strategies The hydrophilic nature of GHK-Cu (log P approximately -2.3) limits passive diffusion through the lipophilic stratum corneum, necessitating penetration enhancement strategies for optimal topical delivery

[DOI] [PubMed] [Google Scholar] Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, et al

Microorganisms, 10 (9), 1838

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Takeaway: What you should worry about is shaped by land use, source type, and eventsnot just by whether water is treated. Is bottled water, alkaline water, or RO automatically safer than tap water (and why demos like red dye tests mislead)