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The mice had unlimited access to a standard mouse chow diet and water

Furthermore, CUL5-deficient macrophages exhibit a reduced activation threshold in response to IL-4, characterized by increased arginase 1 expression and a marked shift toward an anti-inflammatory phenotype, with upregulation of anti-inflammatory proteins such as Serpinb6a and Aldh5a1 (199)

Of the 50 markers investigated, 4, 11 and 25 serum and plasma analytes were significantly different from controls in mild, moderate and severe groups, respectively after false discovery rate (FDR) correction and included several well-defined pro-inflammatory cytokines, including interferon- (IFN), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-1RA (IL-1RA), interleukin-8 (IL-8) and 10 kDa interferon gamma-induced protein (IP-10)

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